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ROLE SUMMARY The primary role of this position is to contribute to RNA Platform improvements to help advance Pfizer's RNA vaccine programs. The candidate will work closely with the mRNA Platform
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Develop an integrated framework connecting multi-omics data analysis and ML algorithm to enhance vaccine target selection and optimization strategy Work with platform leadership to shape and inform key RNA
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the functional consequences of genetic (CRISPR-based gene editing technologies and RNA interference) and chemical perturbations in cell-based model systems Develop cellular tools for advancing drug
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. The candidate will be encouraged to bring innovative approaches to tackle complex protein and RNA biology and diverse targeting modalities. As part of this early discovery group, the individual will
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, characterization and commercial manufacturing support of: recombinant proteins, RNA vaccines, conjugated polysaccharide vaccines, monoclonal antibodies including bispecific, enzymes, and localization programs
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adaptive immune response. Extensive experience in analyzing multi-omics data (e.g., genetics, bulk RNA-seq, single-cell RNA-seq, spatial omics, proteomics, etc.) for biomedical research. Proficient coding
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DNA constructs and performing high-throughput processes for macromolecule production (DNA, RNA, and protein) and DNA sequencing. The candidate will also be responsible for updating the laboratory
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biology to solving biomedical problems. Extensive experience in analyzing multi-omics data (e.g., genetics, bulk RNA-seq, single-cell RNA-seq, spatial omics, proteomics, etc.) for biomedical research
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to support epigenomic data analysis including ATAC-seq, ChIP-seq, Cut&Run, RNA-seq and Bru-seq. Expertise with using R for data analysis and visualization is highly desirable. Preference for candidates with a
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research and the targeting of epigenetic pathways by small-molecule inhibitors. Expertise in techniques used for epigenetic/ transcriptional profiling including ChIP-seq, ATAC-seq, nascent and bulk RNA-seq